2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-G0008
    O-Desmethyl Mebeverine alcohol 155172-67-1 98%
    O-Desmethyl Mebeverine alcohol is a metabolite of Mebeverine, which is a potent α1 repector inhibitor, causing relaxation of the gastrointestinal tract.
    O-Desmethyl Mebeverine alcohol
  • HY-I1198
    Dapagliflozin keto impurity 2169998-23-4 98.19%
    Dapagliflozin keto impurity (Oxo-dapagliflozin) is a metabolite and impurity of Dapagliflozin (HY-10450). Dapagliflozin (BMS-512148) is a competitive inhibitor of sodium-glucose cotransporter 2 (SGLT2).
    Dapagliflozin keto impurity
  • HY-N0312
    Rhein-8-glucoside calcium 113443-70-2 98%
    Rhein-8-glucoside calcium, an anthraquinone compound, is isolated from the EtOH extract of the roots of Saussurea lappa. Rhein-8-glucoside calcium is an hPTP1B inhibitor, with an IC50 of 11.5 μM. Rhein-8-glucoside calcium has antibacterial effects.
    Rhein-8-glucoside calcium
  • HY-N1002
    Cadin-1(14)-ene-7a,11-diol 658062-23-8 98%
    Cadin-1(14)-ene-7a,11-diol is a sesquiterpene alcohol with melanogenesis inhibitory activity. Cadin-1(14)-ene-7a,11-diol inhibits the melanogenesis in B16 melanoma cells induced with α-MSH (HY-P0252). Cadin-1(14)-ene-7a,11-diol can be used as a potential skin-whitening agent.
    Cadin-1(14)-ene-7a,11-diol
  • HY-N1006
    10-Hydroxyscandine 119188-47-5 98%
    10-Hydroxyscandine is an alkaloid from Melodinus tenuicaudatus. 10-Hydroxyscandine can be used for the research of hernia, dyspepsia, abdominal pain, and rheumatic heart.
    10-Hydroxyscandine
  • HY-N1097
    Venoterpine 17948-42-4 98%
    Venoterpine (RW 47) is a natural product. Venoterpine shows anti-aging activities.
    Venoterpine
  • HY-N1118
    Triptotriterpenic acid A 84108-17-8 98%
    Triptotriterpenic acid A is a natural product from Tripterygium wilfordii.
    Triptotriterpenic acid A
  • HY-N1186
    Tachioside 109194-60-7 98%
    Tachioside inhibits nitric oxide production in lipopolysaccharide (HY-D1056)-stimulated RAW 264.7 cells with IC50 value of 12.14 μM. Tachioside has anti-obesity, antioxidant and α-glucosidase inhibitory activities.
    Tachioside
  • HY-N1283
    Seneciphyllinine 90341-45-0 98%
    Seneciphyllinine, a pyrrolizidine alkaloid, is isolated from the roots of Gynura japonica. Pyrrolizidine alkaloids are highly hepatotoxic natural chemicals that produce irreversible chronic and acute hepatotoxic effects on human beings.
    Seneciphyllinine
  • HY-N1326
    Santamarine 4290-13-5 98.85%
    Santamarine (Santamarin; Balchanin) is a sesquiterpene lactone found in Artemisia scoparia. Santamarine shows anti-inflammatory, antioxidant, anticancer and anti-photoaging activities. Santamarine suppresses UVA-induced phosphorylation of JNK and p38 MAPK, nuclear translocation of phosphorylated c-Fos and c-Jun, and AP-1-mediated MMP-1 transcription and secretion. Santamarine suppresses NF-κB signaling, iNOS, COX-2, TNF-α, and IL-1β production. Santamarine inhibits thioredoxin reductase activity, induces ROS production, mitochondrial apoptosis, G2/M cell cycle arrest, and DNA damage, and reduces cancer cell growth. Santamarine can be used for the photoaging, inflammatory diseases and cancer.
    Santamarine
  • HY-N1556
    Psidial A 1207181-35-8 98%
    Psidial A is an epimer of sesquiterpenoid-diphenylmethane meroterpenoid. Psidial A may act as a selective estrogen receptors modulator. Psidial A also has potential for anticancer research.
    Psidial A
  • HY-N1623
    1-Hydroxy-2,3,4,7-tetramethoxyxanthone 14103-09-4 98%
    1-Hydroxy-2,3,4,7-tetramethoxyxanthone is a metabolite of xanthone that can be found in Halenia elliptica D. Don.
    1-Hydroxy-2,3,4,7-tetramethoxyxanthone
  • HY-N1680
    3,7-Dimethyloct-1-ene-3,6,7-triol 73815-21-1 98%
    3,7-Dimethyloct-1-ene-3,6,7-triol is a class of monoterpenoid polyols. 3, 7-dimethyloct-1-ene-3,6,7-triol has anti-HIV activity. 3, 7-dimethyloct-1-ene-3,6,7-triol can be used to study the isolation method of this drug from natural fruit ofCnidium monnieri .
    3,7-Dimethyloct-1-ene-3,6,7-triol
  • HY-N1729
    2α-Hydroxy-1,8-cineole 60761-00-4 98%
    2α-Hydroxy-1,8-cineole is a metabolite of 1,8-cineole (HY-N0066).
    2α-Hydroxy-1,8-cineole
  • HY-N1743
    1-(4-Hydroxy-2-methoxyphenyl)-3-(4-hydroxy-3-prenylphenyl) 376362-03-7 98%
    1-(4-Hydroxy-2-methoxyphenyl)-3-(4-hydroxy-3-prenylphenyl), isolated from Broussonetia kazinoki, shows in vitro inhibition of protein tyrosine phosphatase 1B (PTP1B) with an IC50 of 13.00 μM. PTP1B is a negative regulator of insulin action and an important mediator in the pathogenesis of insulinresistance and non-insulin dependent diabetes mellitus. PTP1B is regarded as a significant target for type 2 diabetes.
    1-(4-Hydroxy-2-methoxyphenyl)-3-(4-hydroxy-3-prenylphenyl)
  • HY-N1797
    3,7-Di-O-methylducheside A 136133-08-9 98%
    3, 7-di-o-methylducheside A (Compound 2) is a ethyl acetate extract of Psittacanthus cucullaris. 3, 7-di-o-methylducheside A stimulates the formation of glycosaminoglycan chains. 3, 7-di-o-methylducheside A can be used to study the rate of glycosaminoglycan synthesis .
    3,7-Di-O-methylducheside A
  • HY-N1823
    Pygenic acid A 52213-27-1 98%
    Pygenic acid A is a natural compound that can be found in Prunella vulgaris. Pygenic acid A induces apoptosis in metastatic breast cancer cells. Pygenic acid A can be used for the research of diabetes, inflammatory diseases, and cancers.
    Pygenic acid A
  • HY-N1859
    3'-O-Methylorobol 36190-95-1 98%
    3'-O-Methylorobol, an antioxidant flavonoid, exhibits moderate antioxidant activity in the 2,2-diphenyl-1-picrylhydrazyl free radical scavenging assay.
    3'-O-Methylorobol
  • HY-N1873
    (E)-4-(3,4-Dimethoxyphenyl)but-3-en-1-ol 69768-97-4 98%
    (E)-4-(3,4-Dimethoxyphenyl)but-3-en-1-ol (DMPB) is a natural product that can be isolated from Zingiber cassumunar. (E)-4-(3,4-Dimethoxyphenyl)but-3-en-1-ol can increas melanogenesis.
    (E)-4-(3,4-Dimethoxyphenyl)but-3-en-1-ol
  • HY-N1901
    (E)-p-Coumaramide 194940-15-3
    (E)-p-Coumaramide is an α-Glucosidase inhibitor that can be isolated from Welsh onion.
    (E)-p-Coumaramide
Cat. No. Product Name / Synonyms Application Reactivity